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DR. raul n. Ondarza-vidaurreta professor of Biochemistry, Faculty of Medicine, unam and


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Currículum, 2008
DR. RAUL N. ONDARZA-VIDAURRETA

Professor of Biochemistry, Faculty of Medicine, UNAM and

Medical Researcher, National Institute of Public Health, Health Secretariat.
OLIVAR DE LOS PADRES 941 MEXICO, D. F. 01780

E-mail: ondarza@servidor.unam.mx



He has had extensive experience in teaching biochemistry

and molecular biology to students of Biology and Medicine, in the Faculties of Sciences and Medicine of the Universidad Nacional Autónoma de México. His experience includes directing research theses and providing formal courses for students in both Master’s and Doctor’s degree programs in the University and The National Institute of Public Health, Cuernavaca, Morelos. He has also been an active organizer and director of projects and programs, as well as being involved at research institutions in the fields of ecology and biomedical research.
For twelve years, Dr. Ondarza was Advisor and General Coordinator of Science Committees within CONACYT (1971- 1982) and created five new research centers in several locations within Mexico. These centers are CICESE in Ensenada, B.C.; CIBNOR in La Paz, B.C. Sur ; CIES in San Cristóbal de Las Casas, Chiapas ; CIQA in Saltillo, Coahuila; and CICY in Mérida, Yucatán.
Dr. Ondarza has been “Director of Research” on three separate occasions, the first for a period of seven years (1983-1989) as General Director in the Center of Ecological Research in San Cristóbal de las Casas, Chiapas. This center is dedicated to studies of the biomedical, socioeconomic and agro-ecological problems of the South East of Mexico.
The second activity was in the Foreign Affairs Secretariat of the Government of Mexico, where he acted as General Director of Scientific and Technological Cooperation (1990). Among the various international agreements of collaboration with Europe and Central America, he signed the Agreement between U.S.A. and Mexico, in the Campus of the University of California at San Diego in La Jolla.

The third experience was as Director of the Center of Research for Infectious Diseases, National Institute of Public Health in Cuernavaca, Morelos, for the three-year period 1990-93. Dr. Ondarza is currently appointed at this Center where he has established a group of young researchers working in the biochemistry and molecular biology of human parasites, particularly on Entamoeba histolytica, Acanthamoeba polyphaga and Naegleria fowleri. During his current sabbatical at Scripps ( January 2002 - December 2002), he continued to advise and direct this research program.

Dr. Ondarza’s interests are in the biochemistry and molecular biology of human parasites, as well as other types of pathogens such as Trypanosoma cruzi and in cancer cells infected by the Papilloma virus.

These studies are all relevant to the concept of the discovery of new thiol compounds which are unique to these parasites and also for the related enzymes that can serve as “drug targets”. This approach will permit the discovery of specific drugs that do not affect the human host.



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British Council Scholar, Postgraduate studies in Biochemistry, Glasgow University, Scotland, Great Britain, 1953-54. Chairman Professor James N. Davidson.
Scholarship from the Organization of The American States (OAS) to study and do research on Streptococcus pneumonia, Downstate Medical Center, New York State University, Brooklyn, USA, 1959.
Doctor in Biology (Biochemistry) Faculty of Sciences Universidad Nacional Autonoma de Mexico, December 1963
Fellow John Simon Guggenheim Memorial Foundation, 1963.
Visiting Professor, Scripps Institution of Oceanography, University of California, San Diego at La Jolla, California, School of Science and Engineering, during his first sabbatical year,1964. Chairman Professor David Bonner.
Carnot Prize, Gold Medal and Diploma, National Academy of Medicine, 1968.
Prize of the National Chemical-Pharmaceutical Industry, 1971, Diploma.

Member of the Symposia Organizing Comitee, International Union of Biochemistry (IUB), from 1971 to 1976.


Visiting Professor, Scripps Institution of Oceanography, University of California, San Diego at La Jolla, California, during his second sabbatical, 1982. Chairman Professor Andrew Benson.
Visiting Professor, Scripps Institution of Oceanography, University of California, San Diego at La Jolla, California, during his third sabbatical, 2002. Chairman Professor William Fenical.
Dr. Honoris Causa, Republique Francaise, Ministere de l´Education Nationale, Académie de Créteil, Universitè París Xlll (1984).
Visiting Researcher, Department of Chemistry, University of California, San Diego, at La Jolla, 1986. Professor Robert C. Fahey.
Homage received as "Founder of the Course of Molecular Biology" in 1963, by students of the generation 62-65 from the Faculty of Sciences, (Actuary, Biology, Physics and Mathematics), October 21,1993, Aula Magna 1, Faculty of Sciences, UNAM, University City.
Member of the Editorial Advisory Board. Current Drug Targets- Infectious Disorders. 2001. Bentham Science Publishers.
Member of the Editorial Advisory Board, Current Pharmaceutical Analysis. 2004. Bentham Science Publishers.
Visiting Professor, Scripps Institution of Oceanography, University of California, San Diego at La Jolla, California, during his fourth sabbatical year, 2005. Chairman Professor William Fenical.
Recognition “al Mérito Universitario”, 50 years of Academic Activity Gold Medal and Diploma received “el Día del Maestro”, Mayo 15, 2003. Universidad Nacional Autónoma de México.
Recognition for 50 years of Academic Activity, Gold Medal and Diploma, May 23, 2003, Faculty of Medicine, Universidad Nacional Autónoma de México.
Recognition for 55 years of Academic Activity, Gold Medal and Diploma, May 13, 2008, Faculty of Medicine, Universidad Nacional Autónoma de México.


50 Scientific publications mainly in International Journals, examples:
Ondarza, R. N., Hurtado, G., Tamayo, E., Iturbe, A. and

Hernández, E. Naegleria fowleri: a Free-Living Highly

Pathogenic Amoeba contains Trypanothione/Trypanothione

Reductase and Glutathione/Glutathione reductase Systems.

Experimental Parasitology, March 2007.
Ondarza, R.N. Drug Targets from Human pathogenic Amoebas: Entamoeba histolytica, Acanthamoeba polyphaga and Naegleria fowleri, Infectious Disorders, Drug targets, September 2007 Review
Raúl N. Ondarza, Drug Effects on Drug Targets: Inhibition of Enzymes by Neuroleptics, Antimycotics, Antibiotics and Other Drugs on Human Pathogenic Amoebas and their Antiproliferative Effects, Recent Patents on Anti-Infective Drug Discovery, 2007, Review 2, © 2007 Bentham Science Publishers Ltd.
Author and Editor of 13 Books on general and specific subjects, some examples:
"Mechanisms of Oxidizing Enzymes", North Holland-Elsevier,

1978. Coeditor with Thomas P. Singer. ISBN 0-444-00265-0


"Molecular Basis of Drug Action", North Holland- Elsevier,1981.

Coeditor with Thomas P. Singer. ISBN0-444-00632-X


"Mechanisms of Drug Action", Academic Press,1983. Coeditor with

Thomas P. Singer and T. Manzur. ISBN 0-12-646680-7


9 Chapters in Books, examples:
"Preparation and Assay of CoA-SS-Glutathione". En: Methods in Enzymology, Volumen XVIII: Vitamins and Coenzymes, editado por Donald B. McCormick and Lemuel D. Wright. Academic Press. N.Y, USA, 1970 p. 318-322. ISBN 0-12-181879-9
“Studies on GSSG- and CoASSG reductases from rat liver and yeast”. En: Flavins and Flavoproteins editado por T.P. Singer. Elsevier Scientific Publishing Company, Amsterdam, USA,1976 p. 492-499. ISBN 0-444-41458-4
132 National Conferences and 30 International (Moscù, Paris, Glasgow, Montreal, San Francisco, Buenos Aires, Caracas, Interlaken, Marseille, La Jolla, Houston, Shanghai, Dubai, Honolulu and several other places.
5.- 33 articles in newspapers
6.- 20 Students, BSc, Master and DSc
7.- Member of 10 National and 5 International Societies, National Academy of Medicine and in some of them founder and President , Mexican Academy of Sciences and Mexican Biochemical Society.
8.- 2 International and 3 National Grants


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